Who we are?
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Research & Development
Research and development of applications / interfaces with methods for the analysis, storage, display and reporting of digital images from any type of instrumentation used for imaging diagnostics in the healthcare sector.
Artificial Intelligence
Implementation of artificial intelligence techniques for data analysis.
Technology Transfer
The exploitation, in any form, of the results of the research, of the realized projects, of the acquired knowledge and methodologies.
Training
The specific and technical training concerning the results and products of the research, the projects carried out, the knowledge and the methodologies acquired.
History
The company is based on the skills acquired by the members in their training and professional post-graduate course during which, for various reasons, they have directly created and managed for a long time a complex system of archiving, displaying and processing digital images for the diagnostics in healthcare and research in the field of neuroscience and imaging.
The research group made up of the innovative startup has the technical-design skills related to the medical, neuroscience, engineering, IT, physical fields and boasts more than 150 publications in international journals.
Dr. Massimo Caulo
Co-founder, radiologist
Associate Professor of Neuroradiology, member of the Department of Neurosciences, Imaging and Clinical Sciences of the University “G. d’Annunzio “since 2005, has always been involved in diagnostic neuroradiology with particular regard to functional studies with advanced techniques of magnetic resonance. He is in charge of the Functional Neuroradiology Section of the Italian Neuroradiology Association (AINR) (https://www.ainr.it/sezione-di-neuroradiologia-funzionale/) He is also a first level medical director at the Radiology of the University Polyclinic of Chieti since 2010 and supervisor of the diagnostic Neuroradiology of ASL2 Abruzzo.
Dr. Piero Chiacchiaretta
President, co-founder, physicist
He graduated in Physics with a doctorate in functional Neuroimaging. Main field of research is the study of the BOLD signal (Blood Oxygenation Level Dependent) also specialized in perfusion analysis (ASL) and analysis of connectivity and neural networks. In addition, he has many years of proven experience in the development and management of PACS systems at ITAB (Institute of Advanced Biomedical Technologies). Direct knowledge acquired in the field of solid state Physics, and optoelectronic devices (OLED) at ENEA (Frascati) and the development of relational databases in companies such as La Panoramica s.n.c. (CH).
Dr. Riccardo Navarra
Co-founder, physicist
PhD in Neuroimaging, Master’s Degree in Microelectronics and Degree in Physics. He worked for about four years as a Process Engineer in Plasma Etching area, following the entire production line from bare silicon to the product ready for testing. He held the role of research fellow. It deals with predictive analysis through advanced techniques of Statistics and Artificial Intelligence and implementations of new sequences in Functional Magnetic Resonance with Diffusion weighing for the study of brain variations under different conditions. Complete the profile of leadership, planning and IT skills both as a system administrator and programmer.
Ing. Mauro Gianni Perrucci
Co-founder, engineer
Graduated in microelectronic engineering in 2002 at the University of L’Aquila, he worked for several years in the field of information technology as a network systemmer, hardware technician, sales manager for individuals and public administration. In 2003 he qualified as an engineer. In 2005 he began his doctoral activity at ITAB (Institute of Advanced Biomedical Technologies) and in 2008 he obtained a Ph.D. in Functional Neuroimaging. Since 2011 he has been working as a permanent researcher in the Department of Neurosciences, Imaging and Clinical Sciences and collaborates with various research groups.
Prof. Antonio Ferretti
UdA, physicist
…
Ing. Massimo Di Piero
Phd student , engineer
He graduated in Nuclear Engineering at the University of Pisa. During his studies he carried out training and research activities at the Ministry of Defense in the laboratories of CISAM (formerly CRESAM) and then at the U.O. of Health Physics at the University Hospital of Pisa in the field of Radioprotection. In the last period he carries out research and development activities first in Sogin S.p.A. (Trino Vercellese nuclear plant) and then at the Department of Civil and Industrial Engineering in the field of Decommissioning of Nuclear Installations and Radioprotection that led him to have experiences abroad in the United States and in France. He worked for a short period at SiderPiombino as a Structural Engineer in the nuclear field and in the mobile and immobile heavy structures.
Currently he is the winner of the PhD European Industrial Research PON 2014 – 2020 of the Department of Neurosciences, Imaging and Clinical Sciences of the University of Chieti – Pescara in collaboration with SerVe S.r.l. in which he deals with both artificial intelligence and machine learning applied to the medical field and the neuro images. The research currently in progress is located in the SNSI sector.
Le nostre pubblicazioni internazionali
, 2019. Brainstem evoked potentials and magnetic resonance imaging abnormalities in differential diagnosis of intracranial hypotension. Neurophysiol Clin.
, 2019. Dysembryoplastic Neuroepithelial Tumors: What You Need to Know. World Neurosurg.
, 2019. Comparison of T1 mapping and fixed T1 method for dynamic contrast-enhanced MRI perfusion in brain gliomas. Eur Radiol.
, 2019. Toward a brain theory of meditation. Prog Brain Res 244:207-232
, 2019. EEG microstates distinguish between cognitive components of fluid reasoning. Neuroimage 189:560-573
, 2019. Choice-predictive activity in parietal cortex during source memory decisions. Neuroimage 189:589-600
, 2019. Multiple liver pseudotumors due to hepatic steatosis and fatty sparing: A non-invasive imaging approach. Eur J Radiol Open 6:56-59
, 2019. Spontaneous Brain Activity Predicts Task-Evoked Activity During Animate Versus Inanimate Touch. Cereb Cortex.
, 2019. Safety and effects on motor cortex excitability of five anodal transcranial direct current stimulation sessions in 24hours. Neurophysiol Clin 49(1):19-25
, 2019. Prenatal planning of placenta previa: diagnostic accuracy of a novel MRI-based prediction model for placenta accreta spectrum (PAS) and clinical outcome. Abdom Radiol (NY) 44(5):1873-1882
, 2019. Correlations between cervical spinal cord magnetic resonance diffusion tensor and diffusion kurtosis imaging metrics and motor performance in patients with chronic ischemic brain lesions of the corticospinal tract. Neuroradiology 61(2):175-182
, 2019. Direct Involvement of Cranial Nerve V at Diagnosis in Patients With Diffuse Intrinsic Pontine Glioma: A Potential Magnetic Resonance Predictor of Short-Term Survival. Front Oncol 9:204
, 2018. Performance of diffusion-weighted magnetic resonance imaging at 3.0T for early assessment of tumor response in locally advanced rectal cancer treated with preoperative chemoradiation therapy. Abdom Radiol (NY) 43(9):2221-2230
, 2018. Disrupted relationship between "resting state" connectivity and task-evoked activity during social perception in schizophrenia. Schizophr Res 193:370-376
, 2018. Abnormal BAEP and internal auditory canal MRI in intracranial hypotension. J Neurol Neurosurg Psychiatry 89(4):437-439
, 2018. Safety and effects on motor cortex excitability of five cathodal transcranial direct current stimulation sessions in 25hours. Neurophysiol Clin 48(2):77-87
, 2018. Aortic valve bypass surgery in severe aortic valve stenosis: Insights from cardiac and brain magnetic resonance imaging. J Thorac Cardiovasc Surg 156(3):1005-1012
, 2018. Brain Gliomas: Multicenter Standardized Assessment of Dynamic Contrast-enhanced and Dynamic Susceptibility Contrast MR Images. Radiology 287(3):933-943
, 2018. Diagnostic accuracy of biparametric vs multiparametric MRI in clinically significant prostate cancer: Comparison between readers with different experience. Eur J Radiol 101:17-23
, 2018. Rectal cancer MRI: protocols, signs and future perspectives radiologists should consider in everyday clinical practice. Insights Imaging 9(4):405-412
, 2018. Reduced Dynamic Coupling Between Spontaneous BOLD-CBF Fluctuations in Older Adults: A Dual-Echo pCASL Study. Front Aging Neurosci 10:115
, 2018. Modifications in resting state functional anticorrelation between default mode network and dorsal attention network: comparison among young adults, healthy elders and mild cognitive impairment patients. Brain Imaging Behav 12(1):127-141
, 2018. Near infrared investigation of the infants' brain. Lancet Child Adolesc Health 2(9):626-628
, 2017. Temporal summation of the nociceptive withdrawal reflex involves deactivation of posterior cingulate cortex. Eur J Pain 21(2):289-301
, 2017. Free water elimination improves test-retest reproducibility of diffusion tensor imaging indices in the brain: A longitudinal multisite study of healthy elderly subjects. Hum Brain Mapp 38(1):12-26
, 2017. Functional and neurochemical interactions within the amygdala-medial prefrontal cortex circuit and their relevance to emotional processing. Brain Struct Funct 222(3):1267-1279
, 2017. A Neural "Tuning Curve" for Multisensory Experience and Cognitive-Perceptual Schizotypy. Schizophr Bull 43(4):801-813
, 2017. How spontaneous brain activity and narcissistic features shape social interaction. Sci Rep 7(1):9986
, 2017. GABA content within medial prefrontal cortex predicts the variability of fronto-limbic effective connectivity. Brain Struct Funct 222(7):3217-3229
, 2017. Effects of repetitive TMS of the motor cortex on disease progression and on glutamate and GABA levels in ALS: A proof of principle study. Brain Stimul 10(5):1003-1005
, 2017. Erratum to: GABA content within medial prefrontal cortex predicts the variability of fronto-limbic effective connectivity. Brain Struct Funct 222(8):3861
, 2017. Prematurity and brain perfusion: Arterial spin labeling MRI. Neuroimage Clin 15:401-407
, 2017. Spinal cord microstructure integrating phase-sensitive inversion recovery and diffusional kurtosis imaging. Neuroradiology 59(8):819-827
, 2017. Effect of Continuous Touch on Brain Functional Connectivity Is Modified by the Operator's Tactile Attention. Front Hum Neurosci 11:368
, 2017. "Small World" architecture in brain connectivity and hippocampal volume in Alzheimer's disease: a study via graph theory from EEG data. Brain Imaging Behav 11(2):473-485
, 2016. A frontal but not parietal neural correlate of auditory consciousness. Brain Struct Funct 221(1):463-72
, 2016. Longitudinal reproducibility of default-mode network connectivity in healthy elderly participants: A multicentric resting-state fMRI study. Neuroimage 124(Pt A):442-454
, 2016. Hyperconnectivity of the dorsolateral prefrontal cortex following mental effort in multiple sclerosis patients with cognitive fatigue. Mult Scler 22(13):1665-1675
, 2016. Perinatal MRI diffusivity is related to early assessment of motor performance in preterm neonates. Neuroradiol J 29(2):137-45
, 2016. Test-retest reliability of the default mode network in a multi-centric fMRI study of healthy elderly: Effects of data-driven physiological noise correction techniques. Hum Brain Mapp 37(6):2114-32
, 2016. Transient effects of tumor location on the functional architecture at rest in glioblastoma patients: three longitudinal case studies. Radiat Oncol 11(1):107
, 2016. Dynamic contrast-enhanced and dynamic susceptibility contrast perfusion MR imaging for glioma grading: Preliminary comparison of vessel compartment and permeability parameters using hotspot and histogram analysis. Eur J Radiol 85(6):1147-56
, 2016. Multimodal assessment of hemispheric lateralization for language and its relevance for behavior. Neuroimage 142:351-370
, 2016. Medio-dorsal thalamus and confabulations: Evidence from a clinical case and combined MRI/DTI study. Neuroimage Clin 12:776-784
, 2016. Integrative Processing of Touch and Affect in Social Perception: An fMRI Study. Front Hum Neurosci 10:209
, 2016. Advanced MR imaging in hemispheric low-grade gliomas before surgery; the indications and limits in the pediatric age. Childs Nerv Syst 32(10):1813-22
, 2015. Reversible and Asymptomatic Gyral and Subarachnoid Contrast Enhancement after Carotid Stenting. Neuroradiol J 28(2):184-6
, 2015. O042. Phase-dependent defective functional activity of the default mode network and facilitated temporal processing of nociceptive stimuli in cluster headache. J Headache Pain 16(Suppl 1):A90
, 2015. MRI anatomical variants of mammillary bodies. Brain Struct Funct 220(1):85-90
, 2015. Delineating brachial plexus, cochlea, pharyngeal constrictor muscles and optic chiasm in head and neck radiotherapy: a CT-based model atlas. Radiol Med 120(4):352-60
, 2015. Neural correlates of negative emotion processing in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 60:1-10
, 2015. Resting state BOLD functional connectivity at 3T: spin echo versus gradient echo EPI. PLoS One 10(3):e0120398
, 2015. Comparing 3T T1-weighted sequences in identifying hyperintense punctate lesions in preterm neonates. AJNR Am J Neuroradiol 36(3):581-6
, 2015. Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly. Hum Brain Mapp 36(9):3516-27
, 2015. Advanced Morphological and Functional Magnetic Resonance Techniques in Glaucoma. Biomed Res Int 2015:160454
, 2015. Recurrence of Cerebral Amyloid Angiopathy-Related Inflammation: A Report of Two Cases from the iCAβ International Network. J Alzheimers Dis 46(4):1071-7
, 2015. Cortical Activation During Levitation and Tentacular Movements of Corticobasal Syndrome. Medicine (Baltimore) 94(45):e1977
, 2015. Intertrial Variability in the Premotor Cortex Accounts for Individual Differences in Peripersonal Space. J Neurosci 35(50):16328-39
, 2015. Emotional susceptibility trait modulates insula responses and functional connectivity in flavor processing. Front Behav Neurosci 9:297
, 2015. Dynamic reorganization of human resting-state networks during visuospatial attention. Proc Natl Acad Sci U S A 112(26):8112-7
, 2014. Teaching neuroimages: a dangerous complication of spontaneous intracranial hypotension. Neurology 82(11):e94-5
, 2014. Structural alteration of the dorsal visual network in DLB patients with visual hallucinations: a cortical thickness MRI study. PLoS One 9(1):e86624
, 2014. Do you know what I mean? Brain oscillations and the understanding of communicative intentions. Front Hum Neurosci 8:36
, 2014. Functional connectivity MRI and post-operative language performance in temporal lobe epilepsy: initial experience. Neuroradiol J 27(2):158-62
, 2014. Data-driven grading of brain gliomas: a multiparametric MR imaging study. Radiology 272(2):494-503
, 2014. Framing deductive reasoning with emotional content: an fMRI study. Brain Cogn 87:153-60
, 2014. Multisite longitudinal reliability of tract-based spatial statistics in diffusion tensor imaging of healthy elderly subjects. Neuroimage 101:390-403
, 2014. Relevance of subcortical visual pathways disruption to visual symptoms in dementia with Lewy bodies. Cortex 59:12-21
, 2014. Brain networks during free viewing of complex erotic movie: new insights on psychogenic erectile dysfunction. PLoS One 9(8):e105336
, 2013. Morphological and metabolic changes in the nigro-striatal pathway of synthetic proteasome inhibitor (PSI)-treated rats: a MRI and MRS study. PLoS One 8(2):e56501
, 2013. Pseudocortical and dissociate discriminative sensory dysfunction in a thalamic stroke. Cortex 49(1):336-9
, 2013. Seizure-induced brain lesions: a wide spectrum of variably reversible MRI abnormalities. Eur J Radiol 82(11):1964-72
, 2013. Anatomical segregation of visual selection mechanisms in human parietal cortex. J Neurosci 33(14):6225-9
, 2013. Sensitivity of BOLD response to increasing visual contrast: spin echo versus gradient echo EPI. Neuroimage 82:35-43
, 2013. Long-range functional interactions of anterior insula and medial frontal cortex are differently modulated by visuospatial and inductive reasoning tasks. Neuroimage 78:426-38
, 2012. Behavioral investigation on the frames of reference involved in visuomotor transformations during peripheral arm reaching. PLoS One 7(12):e51856
, 2012. Impaired sustained attention in euthymic bipolar disorder patients and non-affected relatives: an fMRI study. Bipolar Disord 14(7):764-79
, 2012. MR angiography, MR imaging and proton MR spectroscopy in-vivo assessment of skeletal muscle ischemia in diabetic rats. PLoS One 7(9):e44752
, 2012. Modifications of default-mode network connectivity in patients with cerebral glioma. PLoS One 7(7):e40231
, 2012. Common and unique neuro-functional basis of induction, visualization, and spatial relationships as cognitive components of fluid intelligence. Neuroimage 62(1):331-42
, 2012. Reorganization of functional connectivity of the language network in patients with brain gliomas. AJNR Am J Neuroradiol 33(10):1983-90
, 2012. The role of left superior parietal lobe in male sexual behavior: dynamics of distinct components revealed by FMRI. J Sex Med 9(6):1602-12
, 2012. Interspecies activity correlations reveal functional correspondence between monkey and human brain areas. Nat Methods 9(3):277-82
, 2012. Diffusion tensor imaging of subependymal heterotopia. Epilepsy Res 98(2-3):251-4
, 2012. Effects of mobile phone signals over BOLD response while performing a cognitive task. Clin Neurophysiol 123(1):129-36
, 2011. Functional connectivity MR imaging of the language network in patients with drug-resistant epilepsy. AJNR Am J Neuroradiol 32(3):532-40
, 2011. Differential involvement of somatosensory and interoceptive cortices during the observation of affective touch. J Cogn Neurosci 23(7):1808-22
, 2011. Cortical origin of myoclonus in early stages of corticobasal degeneration. Mov Disord 26(8):1567-9
, 2011. Neuronal basis of haedonic appraisal in early onset schizophrenia: FMRI investigation. Neuroradiol J 24(2):264-70
, 2011. Comparison of hypothesis- and a novel hybrid data/hypothesis-driven method of functional MR imaging analysis in patients with brain gliomas. AJNR Am J Neuroradiol 32(6):1056-64
, 2010. Pharmacological functional MRI assessment of the effect of ibuprofen-arginine in painful conditions. Int J Immunopathol Pharmacol 23(3):927-35
, 2010. Passive tactile recognition of geometrical shape in humans: An fMRI study. Brain Res Bull 83(5):223-31
, 2010. Altered brain response without behavioral attention deficits in healthy siblings of schizophrenic patients: an event-related fMRI study. Neuroimage 49(1):1080-90
, 2010. Effects of somatosensory stimulation and attention on human somatosensory cortex: an fMRI study. Neuroimage 53(1):181-8
, 2010. Neural correlates of focused attention and cognitive monitoring in meditation. Brain Res Bull 82(1-2):46-56
, 2010. Persistent genital arousal disorder associated with functional hyperconnectivity of an epileptic focus. Neuroscience 167(1):88-96
, 2010. A difference exists in somatosensory processing between the anterior and posterior parts of the tongue. Neurosci Res 66(2):173-9
, 2009. Differential patterns of cortical activation as a function of fluid reasoning complexity. Hum Brain Mapp 30(2):497-510
, 2009. Large-scale brain networks account for sustained and transient activity during target detection. Neuroimage 44(1):265-74
, 2009. Non-alcoholic partially reversible marchiafava-bignami disease: review and relation with reversible splenial lesions. A case report and literature review. Neuroradiol J 22(1):35-40
, 2009. Unaffected motor cortex remodeling after hemispherectomy in an epileptic cerebral palsy patient. A TMS and fMRI study. Epilepsy Res 85(2-3):243-51
, 2009. Isolated shoulder palsy due to cortical infarction: localisation and electrophysiological correlates of recovery. BMJ Case Rep 2009.
, 2009. A misleading sensory level. J Neurol 256(10):1769-70
, 2009. Is there "neural efficiency" during the processing of visuo-spatial information in male humans? An EEG study. Behav Brain Res 205(2):468-74
, 2009. Negative BOLD during tongue movement: a functional magnetic resonance imaging study. Neurosci Lett 466(3):120-3
, 2009. Noxious somatosensory stimulation affects the default mode of brain function: evidence from functional MR imaging. Radiology 253(3):797-804
, 2009. Asymptomatic spinal cord involvement in posterior reversible encephalopathy syndrome. Neurology 73(18):1507-8
, 2009. Capsular warning syndrome mimicking a jacksonian sensory march. J Neurol Sci 285(1-2):262-4
, 2008. Neurodegenerative diseases. Radiol Clin North Am 46(4):799-817, vii
, 2008. The sense of touch: embodied simulation in a visuotactile mirroring mechanism for observed animate or inanimate touch. J Cogn Neurosci 20(9):1611-23
, 2008. Human secondary somatosensory cortex is involved in the processing of somatosensory rare stimuli: an fMRI study. Neuroimage 40(4):1765-71
, 2008. A frontoparietal network for spatial attention reorienting in the auditory domain: a human fMRI/MEG study of functional and temporal dynamics. Cereb Cortex 18(5):1139-47
, 2007. Low- and high-frequency evoked responses following pattern reversal stimuli: a MEG study supported by fMRI constraint. Neuroimage 35(3):1152-67
, 2007. Isolated shoulder palsy due to cortical infarction: localisation and electrophysiological correlates of recovery. J Neurol Neurosurg Psychiatry 78(1):100-2
, 2007. Human neural systems for conceptual knowledge of proper object use: a functional magnetic resonance imaging study. Cereb Cortex 17(11):2744-51
, 2007. Complete artifact removal for EEG recorded during continuous fMRI using independent component analysis. Neuroimage 34(2):598-607
, 2007. The use of standardized infinity reference in EEG coherency studies. Neuroimage 36(1):48-63
, 2007. Interhemispheric asymmetry of primary hand representation and recovery after stroke: a MEG study. Neuroimage 36(4):1057-64
, 2007. A-magnetic optic-mechanical device to quantify finger kinematics for fMRI studies of bimanual coordination. Brain Topogr 19(3):155-60
, 2007. Electrophysiological signatures of resting state networks in the human brain. Proc Natl Acad Sci U S A 104(32):13170-5
, 2007. New morphologic variants of the hand motor cortex as seen with MR imaging in a large study population. AJNR Am J Neuroradiol 28(8):1480-5
, 2006. Somatotopy of anterior cingulate cortex (ACC) and supplementary motor area (SMA) for electric stimulation of the median and tibial nerves: an fMRI study. Neuroimage 33(2):700-5
, 2006. "What" versus "where" in the audiovisual domain: an fMRI study. Neuroimage 33(2):672-80
, 2006. Mononeuropathy following subcutaneous interferon-beta injection. J Neurol 253(7):961-2
, 2006. Long-term effects of stroke on neuronal rest activity in rolandic cortical areas. J Neurosci Res 83(6):1077-87
, 2005. Neural systems underlying observation of humanly impossible movements: an FMRI study. Cereb Cortex 15(11):1761-7
, 2005. Functional MRI study of diencephalic amnesia in Wernicke-Korsakoff syndrome. Brain 128(Pt 7):1584-94
, 2005. Dynamics of male sexual arousal: distinct components of brain activation revealed by fMRI. Neuroimage 26(4):1086-96
, 2005. Human brain activation during passive listening to sounds from different locations: an fMRI and MEG study. Hum Brain Mapp 26(4):251-61
, 2005. Unusual ipsilateral hyperkinetic automatisms in SMA seizures. Seizure 14(5):354-61
, 2005. The "electrocuted" hippocampus. Lancet 366(9489):956
, 2004. Functional topography of the secondary somatosensory cortex for nonpainful and painful stimulation of median and tibial nerve: an fMRI study. Neuroimage 23(3):1217-25
, 2004. Does cerebrovascular disease affect the coupling between neuronal activity and local haemodynamics? Brain 127(Pt 1):99-110
, 2003. Functional topography of the secondary somatosensory cortex for nonpainful and painful stimuli: an fMRI study. Neuroimage 20(3):1625-38
, 2002. Soft tissue liposarcoma: histological subtypes, MRI and CT findings. Radiol Med 104(3):140-9
, 2002. Neuroradiological findings in two cases of isolated amyloidoma of the central nervous system. Neuroradiology 44(4):333-7
, 2001. [Staging and re-staging of soft tissue sarcoma using MRI. Usefulness of contrast media]. Radiol Med 101(6):444-55
, 2001. Cerebral amyloid angiopathy presenting as nonhemorrhagic diffuse encephalopathy: neuropathologic and neuroradiologic manifestations in one case. AJNR Am J Neuroradiol 22(6):1072-6
, 2001. Acquired inflammatory white matter disease. Childs Nerv Syst 17(4-5):202-10
Publication list retrieved from NCBI using ImpactPubs
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